English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Monotritiomethyl iodide with high specific activity is a valuable reagent for the incorporation of a tritiated methyl group and has attracted much attention in recent years. The reagent can be used for specific tritium labeling of amines, alcohols, and thiols and for C-methylation of peptidic amino acid residues. We recently reported a new procedure for the synthesis of monotritiomethyl iodide by the preparation of chloromethyl esters, followed by tritiodehalogenation with carrier free tritium gas and subsequent cleavage of the ({sup 3}H{sub 1}) ester by lithium iodide. Due to the time necessary for C-Cl bond hydrogenolysis in these esters (normally 12 h), we observed significant isotopic dilution, and the theoretical specific activity was not attainable. Also, in most cases, only 75-80% of the precursor's specific activity could be preserved in the N-methylated products. To overcome these deficiencies, we have continued our investigations and now report a procedure that effectively proceeds with rapid tritium incorporation and essentially no isotope dilution.

Synthesis of monotritiomethyl iodide from thioethers. Hydrogenolysis in the presence of thioethers