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Naesenset. al (Herpes, 8(1), 2001.* Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 10th Edition, McGraw-Hill Medical Publishing Division, 2001, pp. 54-56. Gilbert et al., “Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms” (2002) vol. 5 pp. 88-114.* Nutter et al., “Demonstration of Viral Thymidine Kinase Inhibitor and it’s Effect on Deoxynucleotide Metabloism in Cells Infected with Herpes Simplex Virus'. Antimicrobial Agents and Chemotherapy, vol. 31, No. 3, pp. 368-374, Mar. 1987. Klein et al., “Effect of a Thymidine Kinase Inhibitor (L-653,180) on Antiviral Treatment of Experimental Herpes Simplex Virus Infection in Mice'. Anitviral Research, 14, pp. 207-214, 1990. Manikowski et al., “Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure-Activity Relationships and Antiherpetic Activity in Vivo”. J. Med. Chem., vol. 48, pp.3919-3929, 2005. Naesens et al., “Recent Developments in Herpesvirus Therapy'. Herpes vol. 8, No. 1, 2001. Xu et al., “Synethesis, Properties and Pharmacokinetic Studies of N-Phenylguanine Derivatives as Inhhibitors of Herpes Simplex Virus Thymidine Kinases”. J. Med. Chem... vol. 38, pp. 49-57, 1995. Klein et al., “Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice'. Antiviral Research, vol. 14, pp. 207-214, 1990. Reardon et al., “Herpes Simplex Virus Type I DNA Polymerase Mechanism of Inhibition by Acyclovir Triphosphate'. The Journal of Biological Chemistry, vol. 264, No. 13, pp. 7405-7411, May 1989. Ashton et al., “A Potent. Selective, Non-Substrate Inhibitor Of HSV-1 Thymidine Kinase: (+)-9-II (Z)-2-(Hydroxymethyl)Cyclohexyl Methyl Guanine And Related Compounds'. Nucleosides, Nucleotides, vol. 8, pp. 1157-1158, 1989. Nutter et al., “Demonstration of Viral Thymidine Kinase Inhibitor and Its Effect on Deoxynucleotide Metabolism in Cells Infected with Herpes Simplex Virus'. Antimicrobial Agents and Chemotherapy, vol. 31, No. 3, Mar. 1987.

Manikowski et al.,  Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure-Activity Relationships and Antiherpetic Activity in Vivo