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Hydrogen sulfide (H 2 S) is a biological gasotransmitter that has been employed for the treatment of ischemia-reperfusion injury. Despite its therapeutic value, the implementation of this gaseous molecule for this purpose has required H 2 S-releasing prodrugs for effective intracellular delivery. The majority of these prodrugs, however, spontaneously release H 2 S via uncontrolled hydrolysis. Here, we describe a Ru(II)-based H 2 S-releasing agent that can be activated selectively by red light irradiation. This compound operates in living cells, increasing intracellular H 2 S concentration only upon irradiation with red light. Furthermore, the red light irradiation of this compound protects H9c2 cardiomyoblasts from an in vitro model of ischemia-reperfusion injury. These results validate the use of red light-activated H 2 S-releasing agents as valuable tools for studying the biology and therapeutic utility of this gasotransmitter.

Characterization and Biological Activity of a Hydrogen Sulfide-Releasing Red Light-Activated Ruthenium(II) Complex