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A method for Ni-catalyzed hydroalumination of terminal alkynes, leading to the formation of alpha-vinylaluminum isomers efficiently (&gt;98% conv in 2-12 h) and with high selectivity (95% to &gt;98% alpha), is described. Catalytic alpha-selective hydroalumination reactions proceed in the presence of a reagent (diisobutylaluminum hydride; dibal-H) and 3.0 mol % metal complex (Ni(dppp)Cl(2)) that are commercially available and inexpensive. Under the same conditions, but with Ni(PPh(3))(2)Cl(2), hydroalumination becomes highly beta-selective, and, unlike uncatalyzed transformations with dibal-H, generates little or no alkynylaluminum byproducts. All hydrometalation reactions are reliable, operationally simple, and practical and afford an assortment of vinylaluminums that are otherwise not easily accessible. The derived alpha-vinyl halides and boronates can be synthesized through direct treatment with the appropriate electrophiles [e.g., Br(2) and methoxy(pinacolato)boron, respectively]. Ni-catalyzed hydroaluminations can be performed with as little as 0.1 mol % catalyst and on gram scale with equally high efficiency and selectivity.

journal of the american chemical society

α-Selective Ni-Catalyzed Hydroalumination of Aryl- and Alkyl-Substituted Terminal Alkynes: Practical Syntheses of Internal Vinyl Aluminums, Halides, or Boronates