English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Molecular self-assembly can generate elaborate twoand three-dimensional supramolecular structures through the complementary interaction of attractive and repulsive forces between molecular components and their environment.’ Synthetic self-assembling systems are currently limited to the one-step creation of suprarnolecular structures from molecular components, unlike biological systems which can organize supramolecular assemblies into higher ordered structures to create tissue and functional materials of specific dimensions.z Herein, we report the first observation of a synthetically produced higher ordered self-assembled structure of lipid bilayers with self-limiting dimensions mediated by chemical recognition at the membrane surface. Transmission electron microscopic (TIM) images of the self-assembled material reveal a columnar structure of stacked lipid bilayers uniform in width with lengths spanning dozens of bilayer thickness. Previous work found that liposomes composed of a pyreneIabeled synthetic receptor lipid mixed into a distearylphosphatidylcholine (DSPC) matrix performed as highly selective optical sensors for heavy metal ions?d6 In the absence of metal ions, the liquid-phase receptor lipid separates from the solid-phase DSPC matrix, producing fluorescence spectra with large excimer emission (A= = 470 nm) and relatively small monomer emission (AM = 375 rim). Addition of dior trivalent metal ions causes an inversion of the fluorescence emission peaks (excimer emission attenuates as the monomer emission intensifies), revealing dkpersion of the receptor lipids into the DSPC matrix upon the metrd ion recognition. Complete reversibility of the process was possible by removal of the metal ions with EDTA.

Self-Assembled Columns of Stacked Lipid Bilayers Mediated by Metal Ion Recognition