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Polybrominated diphenyl ethers (PBDEs) have been incorporated into many consumer products as flame retardants. Due to their persistence and ability to bioaccumulate, PBDEs are ubiquitous in human blood and breast milk samples from industrialized nations. Although there exists a potential for environmental pollutants such as PBDEs to adversely impact birth outcomes and perinatal health, reports of PBDE levels in human reproductive tissues are limited. The aim of the current study is to evaluate the total levels and congener-specific profiles of PBDEs from human extraplacental gestational membranes. Gestational membranes from five term pregnancies were obtained from nonlaboring caesarian deliveries at the University of Michigan Women's Hospital Birth Center. Duplicate samples were extracted and analyzed by GC-MS for twenty-one PBDE congeners. Total PBDE loading was 17.4 +/- 3.9 pg/g tissue (5.62 +/- 1.28 ng/g lipid). Seventy-eight percent of the total measurable PBDE loading was due to BDEs 47, 49, 99, 100, and 153, with measured values of 3.63, 3.15, 3.05, 1.74, and 1.90 pg/g tissue (1170, 1018, 983, 561, and 612 pg/g lipid), respectively. The remaining 28% comprised BDEs 17, 28, 66, 71, 85, and 154. No octa-, nona-, or deca-BDEs were identified. Although previously unreported in the human gestational compartment BDE 49 comprised 17% of the total PBDE level. This work establishes baseline accumulated levels of PBDEs in gestational membranes of women in Southeast Michigan.

Polybrominated Diphenyl Ethers in Human Gestational Membranes from Women in Southeast Michigan