English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Interdisciplinary investigation at the interface of chemistry, engineering, and medicine has enabled the development of self-assembled nanomaterials with novel biochemical and electro-optical properties. We have recently shown that emissive polymersomes, polymer vesicles incorporating porphyrin-based fluorophores, feature large integrated-emission oscillator strengths and narrow emission bands; these nanoscale assemblies can be further engineered to fluoresce at discrete wavelengths throughout the visible and near-infrared (NIR) spectral domains. As such, emissive polymersomes effectively define an organic-based family of soft-matter quantum-dot analogs that possess not only impressive optical properties, but also tunable physical and biomaterial characteristics relative to inorganic fluorescent nanoparticles.Here, we expand upon our initial studies on poly(ethyleneoxide)-block-poly(butadiene)-based vesicles to examine fluorophore membrane-loading in other polymersome systems. Through modulation of fluorophore ancilliary group substituents and choice of polymer chain chemistries, we are able to predictably control intramembranous polymer-fluorophore interactions; these phenomena, in turn, influence the nature of fluorophore solvation, local dielectric environment, and emission quantum yield within emissive polymersome assemblies. By utilizing different classes of vesicle-generating diblock copolymers, including bioresorbable poly(ethyleneoxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and poly(ethyleneoxide)-block-poly(gamma-methyl-epsilon-caprolactone) (PEO-b-PMCL), we ascertain general principles important for engineering nanoscale optical vesicles. Further, this work heralds the first generation of fully-biodegradable fluorescent nanoparticles suitable for deep-tissue in vivo imaging.

Controlling Bulk Optical Properties of Emissive Polymersomes through Intramembranous Polymer−Fluorophore Interactions