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The quality of the most commonly used support for solid-phase syntheses, polystyrene resin cross-linked with 1% of divinylbenzene, differs considerably even among different lots of resin from the same source. Determination of the swelling capacity of resins before carrying out solid-phase syntheses represents a very simple means of nondestructive presynthetic resin characterization.

Resins with Identical Specifications Are Not Identical. Identifying a Useful Solid-Phase Resin