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This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples).

Preparation of a Library of Unsymmetrical Ureas Based on 8-Azabicyclo[3.2.1]Octane Scaffold