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Bacterial cells can differentiate into states that allow them to respond efficiently to their environment. An example of such a transformation is the differentiation of planktonic bacteria into highly motile swarmer cells. The hyperflagellated, filamentous swarmer cells can use coordinated movement to seek out and colonize new sites for pathogenic infection. Because the chemotaxis proteins are essential for swarmer differentiation, we sought to probe the relationship between differentiation and chemoattractants. To this end, we developed a method to screen large populations of swarmer cells using flow cytometry. Using this approach, we found that highly potent multivalent chemoattractants can induce the dedifferentiation of swarmer cells. Our results indicate that chemotactic signaling functions as a target for agents that interfere with bacterial swarming. In addition, the identification of ligands that promote the dedifferentiation of swarmer cells offers new strategies for modulating this multicellular behavior.

Flow Cytometry Reveals that Multivalent Chemoattractants Effect Swarmer Cell Dedifferentiation