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We report the design and synthesis of an orthogonally protected peptide nucleic acid (PNA) building block, Fmoc-PNA-U'-(Dde)-OH, and its use in the construction of PNA FRET probes. This building block allows for the post-synthetic attachment of reporter groups to the amino group attached to the 5-position of uracil (U) following selective deprotection of the Dde group. We illustrate the use of this building block for the synthesis of a series of FAM Cy5 donor acceptor pairs and their ability to detect a target DNA sequence.

bioconjugate chemistry

Synthesis of Peptide Nucleic Acid FRET Probes via an Orthogonally Protected Building Block for Post-Synthetic Labeling of Peptide Nucleic Acids at the 5-Position of Uracil