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Thieno[2,3- d ]pyrimidin-4(3 H )-ones are important pharmacophores that previously required a three step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S 8 and formamide. The reported reaction is characterized by step economy, reduced catalyst loading and easy purification.

acs sustainable chemistry and engineering

One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8, and Formamide