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Our growing ability to tailor healthcare to the needs of individuals has thepotential to transform clinical treatment. However, the measurement of multiplebiomarkers to inform clinical decisions requires rapid, effective, andaffordable diagnostics. Chronic diseases and rapidly evolving pathogens in alarger population have also escalated the need for improved diagnosticcapabilities. Current chemical diagnostics are often performed in centralisedfacilities and are still dependent on multiple steps, molecular labelling, anddetailed analysis causing the result turnaround time to be over hours and days.Rapid diagnostic kits based on lateral flow devices can return results quicklybut are only capable of detecting a handful of pathogens or markers. Herein wepresent the use of disposable plasmonics as a platform for low-cost label-freeoptical biosensing with multiplexing capabilities, eliminating the need forflow systems often required in current optical biosensors. We demonstrate thebiosensing capabilities of a system that uses chiroptical measurements as wellas plasmonic enhanced fluorescence from metafilms with shuriken shapednanoindentations. We also perform the detection of SARS-CoV-2 in complexsolutions as an early developmental milestone towards high-throughput,single-step, diagnostic kits for differential diagnosis of multiple respiratoryviruses and any other emerging diagnostic needs. Diagnostics based on thisplatform which we term Disposable Plasmonics Assays, would be suitable forlow-cost screening of multiple pathogens or biomarkers in a near point of caresetting.

Multiplexed Biosensing of Proteins and Virions with Disposable Plasmonic Assays