Open AccessVariable-Sized bis(4-spiro-fused-β-lactam)-Based Unsaturated Macrocycles: Synthesis and Characterization
Author(s) -
Asaad S. Mohamed,
Fatma H. Al-Awadhi,
Nouria A. AlAwadi
Publication year - 2022
Publication title -
acs omega
Language(s) - English
Resource type - Journals
ISSN - 2470-1343
DOI - 10.1021/acsomega.2c05212
Subject(s) - imine , lactam , ketene , diimine , cycloaddition , chemistry , stereochemistry , ring (chemistry) , ring closing metathesis , metathesis , medicinal chemistry , organic chemistry , polymerization , catalysis , polymer
The synthesis with structural identifications including NMR and HRMS spectral data along with single-crystal X-ray diffraction analysis (for 20b , 23b , 25b - 27b ) of a family of 14 new syn / anti bis-4-spiro-β-lactam-based unsaturated macrocycles ( 19a , b-27a , b ), obtained by multistep synthesis including (i) diimine formation, (ii) Staudinger [2 + 2] ketene-imine cycloaddition, and (iii) ring-closing metathesis (RCM), is reported.