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Lithocarpus polystachyus Rehd has received great attention because of its pharmacological activities, such as inhibiting oxidation and lowering blood glucose and blood pressure, and flavonoids are one of its main pharmacodynamic components. It is important to understand the mechanisms of the flavonoid biosynthetic pathway of L. polystachyus , but the regulation of flavonoid biosynthesis is still unclear. In this study, differentially expressed genes and differentially accumulated metabolites in L. polystachyus were studied by integrating transcriptomics and metabolomics technologies. We confirmed the key genes involved in the flavonoid biosynthesis of L. polystachyus , including LpPAL3 , LpCHS1 , LpCHS2 , LpCHI2 , and LpF3H , which had consistent expression patterns with their upstream and downstream metabolites, and there is a significantly positive correlation between them. Compared to mature leaves, stems and young leaves are higher in the expression levels of key structural genes. We deduced that the MYB and bHLH transcription factors regulated the biosynthesis of different flavonoid metabolites and their regulatory patterns. Among them, LpMYB2 , LpMYB20 , LpMYB54 , LpMYB12 , and LpWD40-113 positively regulated the biosynthesis of flavones and flavanones. This discovery preliminarily revealed the pathways and key genes of flavonoid biosynthesis in L. polystachyus , which provided a reference for further study on flavonoid biosynthesis.

Integrative Analysis of Metabolome and Transcriptome Reveals the Mechanism of Flavonoid Biosynthesis in Lithocarpus polystachyus Rehd