Open AccessAnagliptin Protected against Hypoxia/Reperfusion-Induced Brain Vascular Endothelial Permeability by Increasing ZO-1
Author(s) -
Chuo Li,
Yusheng Zhang,
Rongrong Liu,
Yuzhen Mai
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c00242
Subject(s) - viability assay , western blot , endothelial stem cell , downregulation and upregulation , chemistry , mtt assay , reactive oxygen species , reperfusion injury , microbiology and biotechnology , biology , cell , ischemia , medicine , biochemistry , in vitro , gene
Cerebral ischemia-reperfusion injury is commonly induced during the treatment of ischemic stroke and is reported to be related to the blood-brain barrier destruction and brain vascular endothelial cell dysfunction. Anagliptin is a novel antidiabetic agent recently reported to protect neurons from oxidative stress. In the present study, we aim to investigate the protective property of anagliptin against oxygen-glucose deprivation and reperfusion (OGD/R)-induced injury on endothelial cells and clarify the potential underlying mechanism.