Open AccessSilica Magnetic Graphene Oxide Improves the Effects of Stem Cell-Conditioned Medium on Acute Liver Failure
Author(s) -
Tahereh Foroutan,
Fahimeh Kabiri,
Elaheh Motamedi
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c05395
Subject(s) - alkaline phosphatase , mesenchymal stem cell , carbon tetrachloride , ccl4 , necrosis , inflammation , medicine , chemistry , alanine transaminase , matrix metalloproteinase , liver injury , pathology , biochemistry , enzyme , organic chemistry
Acute liver failure (ALF) is usually associated with inflammation and oxidation of hepatocytes and has high mortality and resource costs. Although mesenchymal stem cell-conditioned medium (MSC-CM) has therapeutic effects similar to MSC transplant in treating liver failure, it may not increase survival. On the other hand, graphene-based nanostructures have been proven useful in biomedicine. In this study, we investigated whether silica magnetic graphene oxide (SMGO) improved the effects of MSC-CM in protecting hepatocytes and stimulating the regeneration of damaged liver cells.