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Identification of ligands that selectively activate the M 1 muscarinic signaling pathway has been sought for decades to treat a range of neurological and cognitive disorders. Herein, we describe the optimization efforts focused on addressing key physicochemical and safety properties, ultimately leading to the clinical candidate MK-7622, a highly selective positive allosteric modulator of the M 1 muscarinic receptor that has entered Phase II studies in patients with Alzheimer's disease.

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

MK-7622: A First-in-Class M₁ Positive Allosteric Modulator Development Candidate