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Kidney disease is on the upswing worldwide with increased incidence and prevalence noted. The overall prevalence of chronic kidney disease (CKD) in the general population is estimated to be as high as 14%. In the US alone, we have almost 470 000 people on dialysis, and these individuals could greatly benefit from other options. Transplants are in short supply making tissue engineering/regeneration options look attractive. The kidneys do have a limited capacity for regeneration but are also prone to fibrosis and scarring after injury. The ability to promote a regenerative, rather than fibrotic, response to injury in the kidney could open up an important therapeutic possibility in patients with CKD. The paper by Lih et al. makes an important contribution to this topic by optimizing artificial scaffolds for kidney regeneration.

Building Scaffolds To Rebuild Kidneys