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Ferrocenyl phosphine thioether ligands (PS), not containing deprotonatable functions, efficiently support the iridium catalyzed ketone hydrogenation in combination with a strong base cocatalyst. Use of an internal base ([Ir(OMe)(COD)]2 in place of [IrCl(COD)]2) is not sufficient to ensure activity and a strong base is still necessary, suggesting that the active catalyst is an anionic hydride complex. Computational investigations that include solvent effects demonstrate the thermodynamically accessible generation of the tetrahydrido complex [IrH4(PS)]− and suggest an operating cycle via a [Na+(MeOH)3···Ir–H4(PS)] contact ion pair with an energy span of 18.2 kcal/mol. The cycle involves an outer sphere stepwise H–/H+ transfer, the proton originating from H2 after coordination and heterolytic activation. The base plays the dual role of generating the anionic complex and providing the Lewis acid cocatalyst for ketone activation. The best cycle for the neutral system, on the other hand, requires an energy span...

Ketone Hydrogenation with Iridium Complexes with “non N–H” Ligands: The Key Role of the Strong Base