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Pan-microbial inactivation technologies that do not require hightemperatures, reactive chemical compounds, or UV radiation could address gapsin current infection control strategies and provide efficient sterilization ofbiologics in the biotechnological industry. Here, we demonstrate thatfemtosecond (fs) laser irradiation of resonant gold nanoparticles (NPs) underconditions that allow for E-field mediated cavitation and shockwave generationachieve an efficient plasmon-enhanced photonic microbial pathogen inactivation.We demonstrate that this NP-enhanced, physical inactivation approach iseffective against a diverse group of pathogens, including both enveloped andnon-enveloped viruses, and a variety of bacteria and mycoplasma. Photonicinactivation is wavelength-dependent and in the absence of plasmonicenhancement from NPs, negligible levels of microbial inactivation are observedin the near-infrared (NIR) at 800 nm. This changes upon addition of resonantplasmonic NPs, which provide a strong enhancement of inactivation of viral andbacterial contaminants. Importantly, the plasmon-enhanced 800 nm femtosecond(fs)-pulse induced inactivation was selective to pathogens. No measurabledamage was observed for antibodies included as representative biologics underidentical conditions.

Resonant Gold Nanoparticles Achieve Plasmon-Enhanced Pan-Microbial Pathogen Inactivation in the Shockwave Regime