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Magnetic nanoparticles (MNPs) have been extensively used as contrasts andtracers for bioimaging, heating sources for tumor therapy, carriers forcontrolled drug delivery, and labels for magnetic immunoassays. Here, wedescribe a MNP relaxation dynamics-based magnetic particle spectroscopy (MPS)method for the quantitative detection of molecular biomarkers. In MPSmeasurements, the harmonics of oscillating MNPs are recorded and used as ametric for the freedom of rotational motion, which indicates the bound statesof the MNPs. These harmonics can be collected from microgram quantities of ironoxide nanoparticles within 10 seconds. Using a streptavidin-biotin bindingsystem, we demonstrate the feasibility of using MPS to sense these molecularinteractions, showing this method is able to achieve rapid, wash-freebioassays, and is suitable for future point-of-care (POC), sensitive, andversatile diagnosis.

Magnetic Nanoparticle Relaxation Dynamics-based Magnetic Particle Spectroscopy (MPS) for Rapid and Wash-free Molecular Sensing