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Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes bycatalyzing the decomposition of organic substrates and reactive oxygen species.This mimicry can be found in superoxide radicals and hydrogen peroxides,harmful molecules produced in oxidative stress asso-ciated diseases. Despitethe fact that nanoparticle functionalization is mandatory in the context ofnanomedicine, the influence of polymer coatings on their enzyme-like catalyticactivity is poorly understood. In this work, six polymer coated cerium oxidenanoparticles are prepared by associa-tion of 7.8 nm cerium oxide cores withtwo poly(sodium acrylate) and four poly(ethylene glycol) (PEG) graftedcopolymers with different terminal or anchoring end groups, such as phosphonicacids. The superoxide dismutase-, catalase-, peroxidase- and oxidase-likecatalytic activities of the coated nanoparticles were systematically studied.It is shown that the polymer coatings do not af-fect the superoxidedismutase-like, impair the catalase-like and oxidase-like and surprisinglyim-proves peroxidase-like catalytic activities of cerium oxide nanoparticles.It is also demonstrated that the particles coated with the PEG-graftedcopolymers perform better than the poly(acrylic acid) coated ones asoxidoreductase-like enzymes, a result that confirms the benefit of havingphosphon-ic acids as anchoring groups at the particle surface.

Polymer coated cerium oxide nanoparticles as oxidoreductase-like catalysts