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Herein, we developedcurcumin (Cur)-loaded porous poly(lactic-co-glycolicacid) (pPLGA) nanoparticles (NPs) by the nanoprecipitation method.Dopamine (DA) was then self-polymerized to form a polydopamine (PDA)layer on the surface of the NPs, yielding Cur@pPLGA/PDA NPs that areable to act as both chemotherapeutic and photothermal agents. TheseNPs were further camouflaged with the red blood cell membrane (RBCM)to construct RBCM-Cur@pPLGA/PDA NPs. The RBCM-pPLGA/PDA NPs were around200 nm in size and demonstrated photothermal performance in the near-infrared(NIR) region, with a potent conversion efficiency (35.2%). The blankcarrier has favorable cytocompatibility, but when drug loaded theNPs can efficiently induce the death of cancer cells (particularlywhen combined with NIR laser treatment). Cellular uptake results revealedgreater in vitro uptake of RBCM-Cur@pPLGA/PDA NPsthan bare Cur@pPLGA/PDA NPs in the case of cancer cells but reducedmacrophage phagocytosis. In vivo studies in miceshowed that the RBCM-Cur@pPLGA/PDA NPs exhibited prolonged blood circulationtimes and excellent photothermal properties, allowing tumor-specificchemo-photothermal therapy. The RBCM-Cur@pPLGA/PDA NP platform presentsgreat potential for targeted synergistic cancer treatments.

Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer