Open AccessHighly Enantioselective Hiyama Cross-Coupling via Rh-Catalyzed Allylic Arylation of Racemic Allyl Chlorides
Author(s) -
Jesús González,
Philipp Schäfer,
Stephen P. Fletcher
Publication year - 2019
Publication title -
organometallics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.231
H-Index - 172
eISSN - 1520-6041
pISSN - 0276-7333
DOI - 10.1021/acs.organomet.9b00197
Subject(s) - chemistry , enantioselective synthesis , allylic rearrangement , electrophile , aryl , allyl chloride , catalysis , rhodium , organic chemistry , medicinal chemistry , alkyl
Highly enantioselective Hiyama cross-coupling reactions have been achieved through rhodium(I)-catalyzed dynamic kinetic asymmetric transformations between aryl siloxanes and cyclic racemic allyl halides. This process affords valuable enantiomerically enriched aryl-substituted cyclic allyl products and is compatible with heterocyclic allyl chloride electrophiles.
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