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Magnetic resonance force microscopy (MRFM) is a scanning probe techniquecapable of detecting MRI signals from nanoscale sample volumes, providing aparadigm-changing potential for structural biology and medical research. Thusfar, however, experiments have not reached suffcient spatial resolution forretrieving meaningful structural information from samples. In this work, wereport MRFM imaging scans demonstrating a resolution of 0.9 nm and alocalization precision of 0.6 nm in one dimension. Our progress is enabled byan improved spin excitation protocol furnishing us with sharp spatial controlon the MRFM imaging slice, combined with overall advances in instrumentstability. From a modeling of the slice function, we expect that ourarrangement supports spatial resolutions down to 0.3 nm given suffcientsignal-to-noise ratio. Our experiment demonstrates the feasibility ofsub-nanometer MRI and realizes an important milestone towards thethree-dimensional imaging of macromolecular structures.

Magnetic resonance force microscopy with a one-dimensional resolution of 0.9 nanometers