The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function | Zendy

Priya S. R. Naidu | Zendy; Marck Nörret | Zendy; Nicole M. Smith | Zendy; Sarah A. Dunlop | Zendy; Nicolas L. Taylor | Zendy; Melinda Fitzgerald | Zendy; K. Swaminathan Iyer | Zendy

Open Access

The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

Author(s) -

Priya S. R. Naidu,

Marck Nörret,

Nicole M. Smith,

Sarah A. Dunlop,

Nicolas L. Taylor,

Melinda Fitzgerald,

K. Swaminathan Iyer

Publication year - 2017

Publication title -

langmuir

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.042

H-Index - 333

eISSN - 1520-5827

pISSN - 0743-7463

DOI - 10.1021/acs.langmuir.7b02568

Subject(s) - biomolecule , nanoparticle , ethylene glycol , chemistry , biophysics , corona (planetary geology) , pegylation , nanomedicine , glycidyl methacrylate , surface modification , nanotechnology , blood proteins , chemical engineering , materials science , biochemistry , polymer , polyethylene glycol , organic chemistry , copolymer , biology , astrobiology , venus , engineering

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

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