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This is a comment on a recently published paper in Langmuir: Mandal, N. S.;Sen, A. Relative Diffusivities of Bound and Unbound Protein Can ControlChemotactic Directionality. Langmuir 2021, PMID: 34647749 [arXiv:2103.13469].In this study, Mandal and Sen claim to propose a new kinetic model to analyzethe directional movement of enzyme molecules in response to a gradient of theirsubstrate, with the supposedly new prediction that net movement occurs up thesubstrate gradient when the diffusivity of the substrate-bound enzyme is lowerthan that of the unbound enzyme, and movement down the substrate gradient whenthe diffusivity of the substrate-bound enzyme is higher than that of theunbound enzyme. They develop this theoretical scheme to present an alternativeto our previously published theoretical framework [Agudo-Canalejo, J.; Illien,P.; Golestanian, R. Phoresis and enhanced diffusion compete in enzymechemotaxis. Nano Lett. 2018, 18, 2711-2717; arXiv:2104.02394]. We demonstratethat despite their claim, what they present is exactly the same theory as ourwork, and therefore, we conclude that their claim of novelty isunsubstantiated.

Comment on "Relative Diffusivities of Bound and Unbound Protein Can Control Chemotactic Directionality''