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As the infection of 2019-nCoV coronavirus is quickly developing into a globalpneumonia epidemic, careful analysis of its transmission and cellularmechanisms is sorely needed. In this report, we re-analyzed the computationalapproaches and findings presented in two recent manuscripts by Ji et al.(https://doi.org/10.1002/jmv.25682) and by Pradhan et al.(https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes arethe intermediate hosts of 2019-nCoV and that the 2019-nCoV spike proteininsertions shared a unique similarity to HIV-1. Results from ourre-implementation of the analyses, built on larger-scale datasets usingstate-of-the-art bioinformatics methods and databases, do not support theconclusions proposed by these manuscripts. Based on our analyses and existingdata of coronaviruses, we concluded that the intermediate hosts of 2019-nCoVare more likely to be mammals and birds than snakes, and that the "novelinsertions" observed in the spike protein are naturally evolved from batcoronaviruses.

journal of proteome research

Protein structure and sequence re-analysis of 2019-nCoV genome does not  indicate snakes as its intermediate host or the unique similarity between its  spike protein insertions and HIV-1