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Cyclodextrins (CD) are a family of oligosaccharides with a toroid shape,which exhibit a remarkable ability to include guest molecules in their internalcavity providing a hydrophobic environment for poorly soluble molecules.Recently new types of inclusions of alpha CD with alkyl grafted polysaccharidechains (pullulan, chitosan, dextran, amylopectin, chondroitin sulfate) havebeen prepared which are auto assembled into micro and nano platelets. We reportin this paper an extensive investigation of platelets with differentcompositions, including their reversible hydration (Thermo GravimetricAnalysis), crystalline structure (Powder X Rays Diffraction), dimensions andshapes, (Scanning Electron Microscopy Field Emission Gun), thermal properties,solubility and melting (Micro Differential Scanning Calorimetry). Thecrystalline platelets exhibit layered structures intercalating thepolysaccharide backbones and CD complexes hosting the grafted alkyl chains. Themonoclinic symmetry of columnar type crystals suggests a head to tailarrangement of the CDs. The platelets have a preferentially hexagonal shapewith sharp edges, variable sizes, and thicknesses and sometimes show incompletelayers (terraces). The crystal parameters change upon dehydration. Meltingtemperatures of platelets in aqueous solutions exceeds 100 degree. Finally, wediscuss the potential relation between the platelet structure and applicationsfor mucoadhesive devices.

Auto-assemblies of Alpha-Cyclodextrin and Grafted Polysaccharides: Crystal Structure and Specific Properties of the Platelets