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Hypericin can be found in nature in Hypericum perforatum (St. John's Wort)and has become subject of intense biochemical research. Studies report ofantidepressive, antineoplastic, antitumor and antiviral activity of hypericin.Among the variety of potential applications hypericin can be used asphotosensitizer in photodynamic therapy (PDT), where it is brought into cancercells and produces singlet oxygen upon irradiation with a suitable lightsource. Therefore, the photophysical properties of hypericin are crucial for asuccessful application in a medical treatment. Here, we present the firstsingle molecule optical spectroscopy study of hypericin. Its photostability islarge enough to obtain single molecule fluorescence, surface enhanced Ramanspectra (SERS), fluorescence lifetime, antibunching and blinking dynamics.Embedding hypericin in a PVA matrix changes the blinking dynamics, reduces thefluorescence lifetime and increases the photostability. Single molecule SERSspectra show both the neutral and deprotonated form of hypericin and exhibitsudden spectral changes, which can be associated with a reorientation of thesingle molecule with respect to the surface.

Hypericin: Single molecule spectroscopy of an active natural ingredient