English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

All four possible diastereoisomers of phosphinoferrocenyloxazoline (Phosferrox type) ligands containing three elements of chirality were synthesized as single enantiomers. The S  c configured oxazoline moiety (R = Me, i -Pr) was used to control the generation of planar chirality by lithiation, with the alternative diastereoisomer formed by use of a deuterium blocking group. In each case subsequent addition of PhPCl 2 followed by o -TolMgBr resulted in a single P -stereogenic diastereoisomer ( S  c , S  p , S  phos and S  c , R  p , R  phos , respectively). The alternative diastereoisomers were formed selectively by addition of o -TolPCl 2 followed by PhMgBr (( S  c , S  p , R  phos and S  c , R  p , S  phos , respectively). Preliminary application of these four ligand diastereoisomers, together with ( S  c , S  p ) and ( S  c , R  p ) Phosferrox (PPh 2 ), to palladium catalyzed allylic alkylation of rans -1,3-diphenylallyl acetate revealed a stepwise increase/decrease in ee, with the configuration of the matched/matched diastereoisomer as S  c , S  p , S  phos (97% ee).

the journal of organic chemistry

Stereoselective Synthesis of All Possible Phosferrox Ligand Diastereoisomers Displaying Three Elements of Chirality: Stereochemical Optimization for Asymmetric Catalysis