English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The syntheses of β- S -GlcA(1→3)GlcNAc and β- S -Gal(1→3)GlcNAc thiodisaccharides, which can be considered mimetics of the repeating units of hyaluronan and keratan respectively, were achieved by S N 2 displacement of a triflate group allocated at the 3-position of a convenient 2-azido-4,6- O -benzylidene-2-deoxy-β-d-allopyranose precursor by the corresponding nucleophilic suitable protected thioaldoses derived from glucuronic acid (GlcA) and galactose (Gal). The study of the reaction led to the finding that the vinyl azide formed by competitive E2 reaction of the mentioned triflate was an interesting precursor of a new kind of 2,3-dideoxy-2-azido-(1→2) thiodisaccharides through an addition reaction. Determination of the stereochemistry of the new stereocenter at C-2 was achieved by NOESY experiments. Final protecting group manipulation of the (1→3) thiodisaccharides led to a family of derivatives that could be used as building blocks for the synthesis of complex glycomimetics.

the journal of organic chemistry

Synthesis of (1→3) Thiodisaccharides of GlcNAc and the Serendipitous Formation of 2,3-Dideoxy-(1→2)-thiodisaccharides through a Vinyl Azide Intermediate