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Dopamine D 3 receptors (D 3 R) play a critical role in neuropsychiatric conditions including substance use disorders (SUD). Recently, we reported a series of N -(3-hydroxy-4-(4-phenylpiperazin-1-yl)butyl)-1 H -indole-2-carboxamide analogues as high affinity and selective D 3 R lead molecules for the treatment of opioid use disorders (OUD). Further optimization led to a series of analogues that replaced the 3-OH with a 3-F in the linker between the primary pharmacophore (PP) and secondary pharmacophore (SP). Among the 3-F-compounds, 9b demonstrated the highest D 3 R binding affinity ( K  i = 0.756 nM) and was 327-fold selective for D 3 R over D 2 R. In addition, modification of the PP or SP with a 3,4-(methylenedioxy)phenyl group was also examined. Further, an enantioselective synthesis as well as chiral HPLC methods were developed to give enantiopure R - and S -enantiomers of the four lead compounds. Off-target binding affinities, functional efficacies, and metabolic profiles revealed critical structural components for D 3 R selectivity as well as drug-like features required for development as pharmacotherapeutics.

journal of medicinal chemistry

Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D<sub>3</sub> Receptor Antagonists and Partial Agonists

Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D3 Receptor Antagonists and Partial Agonists

Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D₃ Receptor Antagonists and Partial Agonists