Open AccessImpact of DNA Oxidation on Toxicology: From Quantification to Genomics
Author(s) -
Junzhou Wu,
Shana J. Sturla,
Cynthia J. Burrows,
Aaron M. Fleming
Publication year - 2019
Publication title -
chemical research in toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 156
eISSN - 1520-5010
pISSN - 0893-228X
DOI - 10.1021/acs.chemrestox.9b00046
Subject(s) - dna , dna damage , dna replication , genome , oxidative stress , computational biology , dna repair , genomics , dna oxidation , gene , biology , replication (statistics) , chemistry , genetics , biochemistry , virology
Understanding the toxicological implications of deoxyribonucleic acid (DNA) oxidation arising from cellular oxidative stress depends on identifying DNA oxidation products, their location in the genome, and their interaction with repair, replication, and gene expression.
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