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The residential home was investigated to study the endemic virus population. During this study, oral poliovirus vaccine was given to the children and the effect of vaccination on endemic enteroviruses and adenoviruses was investigated. In the light of these findings, the problem of virus interference is discussed. The health of the children is related to their virus infections. We are indebted to Prof. S. D. M. Court and Prof. C. A. Green for the active interest they have taken in this investigation; to Miss J. McQuillin, B.Sc., F.I.M.L.T., for her technical assistance; also to the matron of the home and her staff for their co-operation in supplying the specimens, and to Mr L. J. Whitlock of the Royal Victoria Infirmary and his staff for arranging their transport to the laboratory.

The feeding of oral poliovirus vaccine to a closed community excreting faecal viruses