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1. A description is given of active forms and cysts of an amoeba found in wild London rats, and morphologically identical with  E. histolytica .  2. When inoculated into the caeca of young rats, the amoebae invade the wall and produce lesions.  3. Acute infections produced in experimental rats respond to treatment with emetine hydrochloride.  4. The naturally infected rats were restricted to a localized focus, in which cases of human amoebiasis were discovered, thus providing circumstantial evidence of the human origin of the infection, and throwing light on the possible role of rats as reservoir hosts.

Entamoeba histolytica in wild rats caught in London