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IN a previous communication one of us showed that certain strains of B. typhosus presented marked serological differences. The experiments, to which we now propose to make further reference, were conducted in the following manner. Four strains were taken, and a quantity of agglutinable culture of each strain was prepared and standardised for opacity. These cultures were then used in making parallel daily tests of the serum of a rabbit, successively immunised against three of the strains by means of single intravenous inoculations of their standardised cultures. The general character of the results was in agreement with conclusions reached by one of us in previous work (18991901), but showed still greater serological differences between the strains. Thus, the evidence obtained separated the four strains into two serological groups, two strains falling into each group. The three successive inoculations (on days 1,8 and 16) were made with three different strains, and after each inoculation the titre of the serum rose for the homologous group to a point very greatly higher than its titre for the strains in the heterologous group. These observations have already been figured for the first 14 days of the experiment (loc. cit.). But the whole data obtained during 25 days are now recorded in standard agglutination units (Table I), and the readings for days 7,13,18 and 25, which illustrate the points of special interest, are charted in the accompanying diagram (Chart 1). The cultures used are indicated as T.E., T.L., T.O., and T.T. The rabbit was inoculated intravenously on day 1 with 0-1 c.c. (25 million approximately) of T.L., on day 8 with an equal dose of T.T., and on day 16 with the same dose of T.O. The tests of the serum were put up by one of us, and were read by the other (A. D. G.) who was kept in ignorance of the details of the test before him until the readings had been made and recorded.

An Inquiry into the Nature of the Serological Differences exhibited by different Cultures of a Bacterial Species (B. typhosus)