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Space-time interaction analysis was applied to data from 101 elementary school children who contracted variola minor during an epidemic in Bragança Paulista County, Brazil. One school had two and the other three shifts of students occupying the same classrooms each day. There was no evidence found for excessive numbers of cases to occur among unvaccinated students occupying the same desks or seated near the desks occupied by cases occurring during another shift. Only three cases occurred among the 31 unvaccinated students occupying desks of students with variola from other shifts. Only one of these three subsequent cases occurred at a time interval suggestive of transmission. For the three models tested there was no evidence of space-time interaction between time of onset of the disease and location of desk for pairs of students from different shifts.

Variola minor in Bragança Paulista County, 1956: lack of evidence indicating the influence of contaminated classrooms on spread of the disease