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1. Salmonella paratyphi A possesses a specific Vi antigen essentially similar to that of the Vi antigen of Salm. typhi. 2. O-insensitive strains of Salm. paratyphi A contain more Vi antigen, and are more virulent for mice, than O-sensitive strains. 3. The most suitable strains for the preparation of paratyphoid- A vaccine are those that develop both the Vi and the O antigens in maximum quantities. The methods of selecting the vaccine strain of Salm. paratyphi A and routinely examining the cultures are essentially the same as those applied to the virulent Vi+O form of Salm. typhi. 4. Pure A Vi antiserum is destined to assume importance in the identification of Salm. paratyphi A strains. 5. Kauffmann's erroneous conclusion that Salm. paratyphi A does not develop Vi antigen is critically reviewed.

The Vi antigen ofSalmonella paratyphi A