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We study deformability-based sorting of same-size RBCs via DLD using anin-house integral equation solver. Our goal is to quantitatively characterizethe physical mechanisms that enable the cell separation. To this end, wesystematically investigate the effects of the interior fluid viscosity andmembrane elasticity of a cell on its behavior. In particular, we consider deepdevices in which a cell can show rich dynamics such as taking a particularangular orientation depending on its mechanical property. We have found outthat cells moving with a sufficiently high positive inclination angle withrespect to the flow direction displace laterally while those with smallerangles travel with the flow streamlines. Thereby, deformability-based cellsorting is possible. The underlying mechanism here is cell migration due to thecell's positive inclination and the shear gradient. The higher the inclinationis, the farther the cell can travel laterally. We also assess the efficiency ofthe technique for dense suspensions. It turns out that most of the cells indense suspensions does not displace in the lateral direction no matter whattheir deformability is. As a result, separating cells using a DLD devicebecomes harder.

Sorting same-size red blood cells in deep deterministic lateral displacement devices