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Objective: To evaluate the antiproliferative activity of Calophyllum inophyllum (C.\udinophyllum) fruit extract against human breast cancer cells MCF-7.\udMethods: The cytotoxic effect of C. inophyllum fruit extract against MCF-7 cancer cells was\udevaluated through MTT and CyQuant assays for 24 h and the morphological investigation of\udtreated MCF-7 cells was observed under optical microscope using Giemsa staining.\udResults: The cytotoxic effect of C. inophyllum fruit extract against MCF-7 cancer cells was\udevaluated through MTT and CyQuant assays simultaneously for 24 h after treatment, which\uddemonstrated the inhibition of cell viability with the IC50 values of 19.63 μg/mL and 27.54\udμg/mL, respectively. The preliminary time-based morphological investigation of MCF-7 cells\udtreated with the IC50 value (23.59 μg/mL) of C. inophyllum fruit extract was observed under an\udoptical microscopy via Giemsa staining, which exhibited prominent histological characteristics\udof apoptosis.\udConclusions: This study clearly proved that the proliferation of human breast cancer cell\udMCF-7 was inhibited by C. inophyllum fruit extract resulted from the induction of apoptosis in\udMCF-7 cells

Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7