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Objective: To assess the serum antioxidant trace elements selenium (Se), zinc (Zn) and copper (Cu)\udin cutaneous leishmaniasis patients.\udMethods: In this study, serum Se, Zn and Cu was determined by using atomic absorption\udspectrometry in patients with cutaneous leishmaniasis (n=95). The values were statistically\udcompared between patients and control group (n=100) using One-way analysis of variance (ANOVA).\udResults: Our results showed that there was a significant difference in the values of Se and Zn\udbetween two groups (P<0.000 1 and P<0.01, respectively). Meanwhile, no significant difference in\udlevel of Cu was observed between patients and healthy subjects (P>0.05). Se and Zn levels were\udfound to be (4.33依1.06) and (70.23依19.12) µg/dL in cutaneous leishmaniasis cases, and these values\udwere found statistically lower compared to the controls (11.10依2.37) and (119.61依26.18) µg/dL,\udrespectively.\udConclusions: The observations that host products are released from stimulated leukocytes and\udcould induce metabolic changes similar to an acute-phase response revealed an endocrine role\udfor the immune system. Characteristic changes in trace-mineral metabolism are an integral part\udof the acute-phase response. The changes are usually reflected in decreased serum Se and Zn\udconcentrations

Alterations of serum antioxidant trace elements (Se, Zn and Cu) status in patients with cutaneous leishmaniasis