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Objective: To assess and compare the requirement of preanaesthetic agents to maintain\udanesthesia within the group of control and groups receiving Clonidine and Dexmedetomidine and\udreduction in cost due to reduced intraoperative anaesthetic and analgesics requirement. Method:\udThree groups of control, clonidine and dexmedetomidine were made. Twenty patients of American\udSociety of Anesthesiologist's grade I & II category for ≥ 3 hours of surgery and >18 years of age\udwere involved in the study of six months duration in each group. Hemodynamic variables of all\udpatients were continuously recorded and maintained. Then, during surgery with anesthesiologists\udwe have quantified the amount of drugs spared by use of these alpha2 agonists. Results:\udDexmedetomidine and Clonidine were found hemodynamically stable during intubation compared\udto Control. Dexmedetomidine group showed 25% reduction in Isoflurane and 40% reduction in\udDiclofenac requirement compared to Clonidine group. The average Fentanyl dose was reduced by\ud33% and 44 % in Clonidine and Dexmedetomidine group respectively compared to Control group.\udDiclofenac and propofol requirement was found to be less in dexmedetomidine group than of\udclonidine. Thus, on average for surgery involving Clonidine INR 1065 per patient were charged\udwhile in Dexmedetomidine only INR 833. Significant cost benefit upto INR 463 per patient can be\udachieved with better hemodynamic control by Dexmedetomidine compared to Control requiring\udINR 1296. Conclusions: Intraoperatively dexmedetomidine showed significant cardiovascular\udstability compared to clonidine. Also, Dexmedetomidine group showed significant drug sparing\udeffect of Isoflurane, Thiopentone and Fentanyl than Control group. A clinical pharmacist can\udassist anesthesiologist's in apt selection of drugs

A comparison study of Dexmedetomidine Vs Clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis