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Methods: A questionnaire about disease (type, localization, diagnosis, treatment and surveillance) was distributed to IBD patients who attended outpatient gastroenterology clinic at our Hospital. The answers were categorized as appropriate or inappropriate. Demographic data, education level and features of the disease were recorded. Results: 73 patients were included (41 females) with a mean age of 44 years-old and a mean duration of IBD of 9.4 years. There were 42 patients with Ulcerative Colitis, 29 with Crohn’s disease and 2 with unclassified IBD. The mean of appropriate answers was 53.6%. The type of IBD was correctly marked in 86% of patients whereas the specific localization of the disease was recognized in only 27%. 95% of the responders considered colonoscopy important in diagnosis. Only 55% of the patients were aware of the increased risk of bowel cancer. A better performance in the questionnaire was associated with: younger patients at diagnosis (r = 0.593; p = 0.000) and at the time of the questionnaire (r = 0.451; p = 0.000), a higher education level (F = 5.976; p = 0.001), presence of Crohn’s Disease (65% versus 46%, F = 6.990; p = 0.000), previous hospitalization (60% versus 42%, t = 4.197; p = 0.000) or surgery related to the disease (66% vs 51%, t = 2.401; p = 0.019) and multiple past medications (including 2 anti-tumor necrosis factor therapy) (F = 4.194; p = 0.000). Conclusions: The age, the educational level of the patient and the severity of the disease requiring hospitalization, surgery or aggressive therapy, were associated with a better knowledge of the disease. The low percentage (marginally positive) of appropriate responses highlights the need for better educational strategies.

P516 Discrepancy between fecal biomarkers and their intestinal gene expression in ulcerative colitis: Results from an anti-IL-13 antibody study