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The cardioplegic solution is often given at high flow and pressure following aortic clamping clamping to ensure rapid diastolic arrest. With standard setup in clinical practice, it is easy to exceed 200 mmHg in the aortic root. To investigate whether cardioplegic solution delivery pressure has an influence on myocardial protection, intermittent infusions of crystalloid cardioplegia were given at two different pressures using an in vivo pig model.

High cardioplegic perfusion pressure entails reduced myocardial recovery