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The SELECT (Systolic Evaluation of Lotrel® Efficacy and Comparative Therapies) trial was a randomized, multicenter, prospective, doubleblinded, parallel-group study that compared the effects of amlodipine/ benazepril combination therapy with those of amlodipine and benazepril monotherapies on SBP in patients 55 years of age with systolic hypertension (mean seated SBP 160-200 mm Hg; mean daytime ambulatory SBP 150-200 mm Hg). Eligible patients had newly diagnosed hypertension or had discontinued previous antihypertensive medication. Following a single-blind, 2-4-week, placebo run-in period, patients were randomized to: amlodipine/benazepril 5/20 mg qd, amlodipine 5 mg qd, or benazepril 20 mg qd. Patients were maintained on this treatment for a period of 8 weeks. The primary objective of the study was to compare the effects of combination therapy with those of component monotherapy on mean 24-hour SBP. Secondary objectives were to assess the effects of these therapies on mean 24-hour pulse pressure, 24-hour diastolic BP, incidence of peripheral edema, safety, quality of life, and response and control rates. Primary results will be available for presentation.

american journal of hypertension

Comparison of the effects of amlodipine/benazepril fixed-dose combination therapy vs amlodipine monotherapy on systolic and diastolic blood pressure in stage 2 or stage 3 hypertension: results of the solace trial