English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Reduction in sympathetic vasoconstrictor drive has been hypothesized to be a major mechanism explaining the blood pressure-lowering effects of dietary weight loss, but the evidence to support this notion is derived from strictly Caucasian cohorts. To determine if weight loss also leads to sympathoinhibition in African Americans (AA), the demographic group in the U.S. with the highest prevalence of hypertension, we measured sympathetic nerve activity (SNA) with microneurography in 11 normotensive (NT) young adult AA men and 6 NT young adult AA women before and after 16 weeks of a hypocaloric diet. In the women, 20 lb weight loss led to greater then 50% reduction in SNA (22 3to 10 1 bursts/min) but 24-hour ambulatory blood pressure (BP) was unchanged (116 2/68 1 to 116 3/70 1 mmHg, p ns). In the men however, 24 lb weight loss had no effect on SNA (26 4 to 27 3) but lowered the 24-hour ambulatory BP by 5/4 mm Hg (from 124 2/74 2 to 119 3/70 2 mmHg, P 0.05). To explore the mechanism of the blood pressure lowering effect of weight loss in these men, we measured 24-hour urinary sodium excretion and found that the 24-hour BP fell only in the men who had reduced their sodium intake along with the hypocaloric diet. In 6 men in whom urinary sodium excretion fell markedly from 165 11 to 45 17 meq/day, 24-hour BP fell by 8/6 mm Hg (from 123 4/74 5 to 115 3/68 3 mmHg) over the 16 week protocol, whereas in the 5 men in whom urinary sodium excretion did not fall, 24-hour BP remained unchanged despite comparable amounts of weight loss in both subgroups. Thus, in women, a substantial reduction in SNA with weight loss was not sufficient to lower BP whereas in men a small but significant reduction in blood pressure was closely linked to reduced dietary sodium intake and dissociated from SNA. These prospective data in normotensive young adult AA men and women call in to question the importance of the sympathetic nervous system in producing the blood pressure lowering effect of dietary weight loss.

Is sympathetic nervous system important in mediating blood pressure lowering effect of weight loss ?