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Hydrogen peroxide (H(2)O(2)) has been shown to induce vascular smooth muscle cell contraction in vitro. In this study, the effect of endogenously produced H(2)O(2) on blood pressure (BP) was examined using a transgenic mouse model (hCatTg(+/0)) in which catalase is overexpressed.

Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice