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group). After one year systolic BP (SBP) was reduced on the average been 168 ± 26 to 158.2 ± 21 mmHg, diastolic BP (DBP) from 102 ± 12.7 to 97 ± 11 mmHg. LV mass index was reduced from 163 ± 32 to 150.2 ± 27 g/m2 (all p<0.001). 22 patents (30.1%) lost weight more than 5%. These patients significantly decreased LV mass 309 ± 79 vs 278.4 ± 61 g; t=3.22 p<0.004), LV mass index (161 ± 35 vs 148 ± 29 kg/m²; t=2.68; p<0.02), LV diastolic dimension (52.3 ± 4.7 vs 50.5 ± 4.4 mm; t=2.95, p<0.008), Cornell's index (1.55 ± 0.4 vs 1.41 ± 0.4, p<0.02), peak double product (DP) (27.3 ± 5 vs 24.4 ± 5, t=2.8, p<0.02), DP/METTs (2.48 ± 1 vs 1.84 ± 1, t=2,15; p< 0.05), mean 24h systolic BP (SBP) (144.1 ± 17 vs 138.6 ± 16 mmHg, t=2.2 p<0.04), mean 24h diastolic BP (DBP) (89.5 ± 11 vs 85.7 ± 12 mmHg, t = 2.2, p<0.04), mean SBP per day (148.2 ± 18 vs 141 ± 16 mmHg, t=2.6, p<0.02), mean DBP per day (92.7 ± 11 vs 88 ± 13 mmHg, t=2.6, p < 0.02) and increase of mean 24h RR intervals per night (938.2 vs 999 ms; t= 3, p<0,007). Patients (51.70%) who didn't achieve significant loss of weight significantly decreased LV mass index (163 ± 30 vs 152 ± 25 kg/m²; t=2.1; p<0.05), office SBP (170.3 ± 27 vs 158.9 ± 19, t=2.2, p<0.03), grades of ventricular arrhythmias (2.73 vs 1.95, t=2.1, p<0.04), and mean VES/24h (66.6 vs 20, t=2.22, p<0.04). Hypertensive patients with LVH with significant loss of weight after one year, achieved higher grade of LVH regression (on account of decrease of LV diastolic dimension), lower DP at exercise, lower values of BP during 24- hour monitoring and improvement of heart rate variability, than patients without significant loss of weight.

Relationship between obesity decrease and regression of hypertensive left ventricular hypertrophy